Dr. Crean graduated with a BSc (Hons) in the biomedical sciences from the Dublin Institute of technology. He subsequently undertook PhD research in the area of ischemia, metabolism and inflammation biology under the supervision of Prof. Cormac Taylor and Dr. Martin Leonard in University College Dublin (UCD). Following the award of PhD, Dr. Crean began a PostDocoral Fellow position in the laboratory of Prof. Evelyn Murphy (UCD) where his research focused on the role of nuclear receptor family 4A [NR4A] receptors as key regulators of inflammatory pathways. Subsequent to this Dr. Crean became a Hoffman-La Roche Fellow in collaboration with Prof. Catherine Godson (UCD) and there investigated, using multidisciplinary approaches, novel mechanisms for the treatment of fibrosis and inflammation in diabetic renal disease. Dr. Crean's key areas of research interest are inflammation and metabolism and currently his group is investigating 1.) The role of NR4A genes in regulating NF-?B signaling in immune cells 2.) The role of NR4A genes in the resolution of inflammation and fibrosis 3.) Novel therapeutics, such as BMP-7 mutants and incretin hormones, for the treatment of fibrosis and inflammation.
- Post-doctoral Research Fellow level 1 [PD1], University College Dublin, IrelandUniversity College Dublin2 Jul 2012 - 20 Dec 2013
- Assistant Lecturer in MSc ¿Pharmacology Quality Control Assurance and Biotechnology¿, course code DT233Dublin institute of technology, Ireland2 Sep 2013 - 6 Jul 2015
- Research FellowHoffman-La Roche13 Jan 2014 - 28 Aug 2015