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Professor Dolores Cahill

Professor

Dolores Cahill

Full Professor
School of Medicine
01 716 6967
University College Dublin, School of Medicine, Conway Institute Belfield Dublin 4

BIO

Prof. Dr Dolores Cahill is a world-wide renowned expert in high-throughput proteomics technology development and automation, high content protein arrays and their biomedical applications, including in biomarker discovery and diagnostics. Prof. Cahill pioneered this research area at the Max-Planck-Institute of Molecular Genetics in Berlin, Germany, and holds several international patents in this field with research, biomedicine and diagnostic applications. o Over 20 years expertise in high-throughput protein & antibody array, automation, proteomics technology development & biomedical applications in biomarker discovery, diagnostics & personalised medicine. o Since 2005 to present, Full Professor of Translational Science, School of Medicine, University College Dublin, Academic, Researcher, Lecturer, Module Coordinator in Pathology Teaching, School of Medicine & Conway Institute o 15 years as Irish, EU & international expert & advisor including Seconded National Expert to European Commission o Company Co-founder & Shareholder (1997-2019) of Protagen AG in Germany (https://protagen.com/). Protagen Protein Services (2012-2019) contract services to healthcare sector & pharmaceutical industry (https://protagenproteinservices.com/). o Since 2016, co-founding shareholder and Advisory Board member of Prof. Stephen Pennington’s UCD School of Medicine/Conway Institute spin-out company, Atturos Ltd. working to improve Prostate Cancer diagnosis (http://atturos.com/ and http://atturos.com/company/advisors/). o Prof. Cahill has a total of over 5940 Citations, H (Hirsh)-index of 35, i10-index of 48. o Project management: Has successfully obtained and project managed as Principal Investigator eight EU Programme funding grants from FP4, FP5, FP6, FP7 and Horizon 2020, Science Foundation Ireland, Enterprise Ireland, Health Research Board funding in companies and universities. Selected Academic Leadership and Contributions: Member of Committees and Awards: o Vice Chair, European Union Innovative Medicines Initiative Scientific Committee (2018-2021) and Member, European Union Innovative Medicines Initiative Scientific Committee (2016-2021) and Vice-Chair (2018-2021) (https://www.imi.europa.eu/sites/default/files/uploads/documents/About-IMI/Governance/sc/IMI_SC_Bio_Dolores_Cahill.pdf). o In 2013-2014, worked in European Commission, Brussels seconded full-time, as a Seconded National Expert (SNE) to the European Commission Research & Innovation (HORIZON2020) (DG RTD) Directorate, in a Strategy and Policy Development role for International R&D&I Cooperation between the EU & Asia (S. Korea, China, ASEAN) & for the Coordination of Health Research, Development and Innovation globally. o In 2005, appointed by the Irish Prime Minister (Taoiseach) & Minister for Health as an Irish Government’s Advisory Science Council (ASC) Member (www.sciencecouncil.ie) (2005-2013) & to develop Irish Strategy for Science, Technology & Innovation (2006-2013) with Universities, Industry & Health, Education, Enterprise & Finance Depts. o Chaired the ASC Task Force ‘Towards a Framework for Researcher Careers’ & ASC Task Force member Report on ‘Promoting Enterprise-Higher Education Relationships’ (2009) and ‘Sustainability of Research Centres’ (2012) o Honoured with a lifetime award from the Federation of European Biochemical Societies Award in Norway (2009) for her research & its significance. Other awardees: Prof. J. Craig Venter & Nobel Prize winner, Prof. Robert Huber. o Awarded the prestigious BMBF BioFuture Prize by German Minister of Science (€1.5million) (2000). o Supervisor of over 20 completed PhD & Masters’ degrees in total. Chair of ten UCD PhD committees. Project management, Research and Peer-Reviewed Publications: o Prof. Cahill has a Hirsch h-index 35: i10-index 48. o Citations 5946 Google Scholar Citations: https://scholar.google.com/ Selected Academic Leadership and Contributions: Invited Speaker, Keynotes, Conferences organised: o Prof. Cahill has given over 100 Keynotes in USA, Europe, China, Japan, S. Korea, Australia, South America: - 18th-19th May 2020: Chair, Global Bioprocessing, Bioanalytics & ATMP Manufacturing, Dublin. - 18th-19th June 2020: Keynote Speaker, BioTech Pharma Summit, CBB 2020, Portugal. - 24th-25th Sept 2020: Guest Speaker, Biotechnology Business Workshop, British Embassy & Biotech Atelier Sofia. - 8th-9th October 2020: Keynote Speaker, Global Engage, Liquid Biopsies Conference, London. - 13th-14th February 2019: Keynote Speaker Companion Diagnostics & Biomarkers Conference 2019 - 13th-15th March 2019: Speaker, Intergovernmental meeting in Bulgaria - 10th -11th October 2019: Chair and Speaker, Immuno-oncology, London (http://www.giiconference.com/gel745785/) - 13th-14th September 2018: Speaker, 5th Precision Medicine & Biomarkers Leaders’ Summit, Munich & Chair of Roundtable on Personalised Medicine & Adverse Events (http://www.giiconference.com/gel560004/catalog.pdf?1528437050). o 9th March 2020: Prof. Cahill invited to speak on the panel ‘A View from the Top: UCD Medicine Female Professors in Conversation’ to mark International Women's Day 2020 (https://www.ucd.ie/medicine/whatson/title,485524,en.html) o 17th-21st September 2017: HUPO2017: Human Proteome Organising (HUPO) Committee Member. The Annual HUPO World meeting was held in Dublin. UCD Prof. Stephen Pennington was Conference Chair. Prof. Cahill was HUPO 2017 Chief Financial Officer (http://hupo2017.ie/?team=prof-dr-dolores-cahill) & had over 1300 attendees with 90% from outside Ireland. Total budget € 1,300,000 & small profit made was returned to the sponsor, British Proteome Society. USA Vice-President (http://hupo2017.ie/news-2/) launched Global Cancer Moonshot at Conference Gala dinner. Selected Peer Reviewed Publications: · Medical Errors & Adverse Events: leading cause of death and disease burden. Cahill, Dolores (2018) Health Europa: 7:42-43. (http://edition.pagesuite-professional.co.uk/html5/reader/production/default.aspx?pubname=&edid=73e202a8-1e25-4d2e-afc3-1cd95c26e5ae) ·Anti-ribosomal-phosphoprotein autoantibodies penetrate to neuronal cells via neuronal growth associated protein (GAP43), affecting neuronal cells in-vitro. Kivity, Shaye; Shoenfeld, Yehuda; Arango, Maria Terresa; Cahill, Dolores J; O'Kane, Sara Louise; Zusev, Margalit; Slutsky, Inna; Harel-Meir, Michal; Chapman, Joab; Mathias, Torsten; Blank, Miri. (2017) Rheumatology RHE-15-1025. · Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis D. R. Christiansona, A. S. Dobroffb, B. Pronetha,A. J. Zuritad, A. Salameha, et al., D. J. Cahill, J. E. Gershenwaldg, R. L. Sidmanj, Wadih Arap, R. Pasqualini (2015) Proceedings of the National Academy of Sciences PNAS USA 2015 Feb 6. pii: 201424994. PMID: 25659743 www.pnas.org/cgi/doi/10.1073/pnas.1424994112. · Highly sensitive toxin microarray assay to improve Aflatoxin B1 detection in food. Beizaei A, O’ Kane SL, Kamkar A, Misaghi A, Henehan G, Cahill DJ. (2015) Food Chemistry Vol 57: 210–215 DOI:10.1016/j.foodcont.2015.03.039. ·The Functional Bionano Interface–Mapping the Interactions at the Interface Between the Hard and Soft Protein Corona. O’Connell DJ, Baldelli Bombelli F, Cahill DJ and Dawson KA. (2014) Nanoscale: Sept 1: DOI: 10.1039/c5nr01970b ·Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays. Murphy MA, O'Connell DJ, O'Kane SL, O'Brien JK, O'Toole S, Martin C, Sheils O, O'Leary JJ, Cahill DJ. Journal Proteomics. (2013) 75(15):4668-75. PMID: 22415278. · Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Staquicini FI, Cardó-Vila M, Kolonin MG, Trepel M, Edwards JK, Nunes DN, Sergeeva A, Efstathiou E, Sun J, Almeida NF, Tu SM, Botz GH, Wallace MJ, O'Connell DJ, Krajewski S, Gershenwald JE, Molldrem JJ, Flamm AL, Koivunen E, Pentz RD, Dias-Neto E, Setubal JC, Cahill DJ, Troncoso P, Do KA, Logothetis CJ, Sidman RL, Pasqualini R, Arap W. Proc Natl Acad Sci U S A. (2012) 108(46):18637-42. PMID: 22049339. ·Assessment of the humoral immune response to cancer. Murphy MA, O'Leary JJ, Cahill DJ. Journal Proteomics. (2012) 3;75(15):4573-9. PMID: 22300580. · Proteomic analysis & discovery using affinity proteomics and mass spectrometry. Olsson N, Wingren C, Mattsson M, James P, O'Connell D, Nilsson F, Cahill DJ, Borrebaeck CA. Mol Cell Proteomics. (2011) 10(10):M110.003962. PMID: 21673276. · Optimized autoantibody profiling on protein arrays. O'Kane SL, O'Brien JK, Cahill DJ. Methods Mol Biol. (2011) 785:331-41. PMID: 21901610. · Probing calmodulin protein-protein interactions using high-content protein arrays. O'Connell DJ, Bauer M, Linse S, Cahill DJ. Methods Mol Biol. (2011) 785:289-303. PMID: 21901608. · Protein networks involved in vesicle fusion, transport, and storage revealed by array-based proteomics. Bauer M, Maj M, Wagner L, Cahill DJ, Linse S, O'Connell DJ. Methods Mol Biol. (2011) 781:47-58. PMID: 21877276. · Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion. Bauer MC, O'Connell DJ, Maj M, Wagner L, Cahill DJ, Linse S. Mol Biosyst. (2011) Jul;7(7):2196-204. PMID: 21528130 · Drug profiling: knowing where it hits. Merino A, Bronowska AK, Jackson DB, Cahill DJ. Drug Discovery Today. (2010) Sep;15(17-18):749-56. Epub 2010 Jun 18. PMID: 20601095. ·Integrated protein array screening and high throughput validation of 70 novel neural calmodulin-binding proteins. O'Connell DJ, Bauer MC, O'Brien J, Johnson WM, Divizio CA, O'Kane SL, Berggård T, Merino A, Akerfeldt KS, Linse S, Cahill DJ. Mol Cell Proteomics. (2010) Jun;9(6):1118-32. Epub 2010 Jan 12. PMID: 20068228. ·Diagnostic and prognostic biomarker discovery strategies for autoimmune disorders. Gibson DS, Banha J, Penque D, Costa L, Conrads TP, Cahill DJ, O'Brien JK, Rooney ME. Journal Proteomics. (2010) Apr 18;73(6):1045-60. Epub 2009 Dec 5. Review. PMID: 19995622. · Calmodulin binding to the polybasic C-termini of STIM proteins involved in store-operated calcium entry. Bauer MC, O'Connell D, Cahill DJ, Linse S. Biochemistry. (2008) Jun 10;47(23):6089-91. PMID: 18484746. ·ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, et al., Skerra A, Templin M, Ueffing M, Uhlén M. Nature Methods. (2007) Jan;4(1):13-7. PMID: 17195019. · Profiling humoral autoimmune repertoire of dilated cardiomyopathy (DCM) patients and development of a disease-associated protein chip. Horn S, Lueking A, Murphy D, Staudt A, Gutjahr C, Schulte K, König A, Landsberger M, Lehrach H, Felix SB, Cahill DJ. Proteomics. (2006) Jan;6(2):605-13. PMID: 16419013. · High throughput identification of potential Arabidopsis mitogen-activated protein kinases substrates. Feilner T, Hultschig C, Lee J, Meyer S, Immink RG, Koenig A, Possling A, Seitz H, Beveridge A, Scheel D, Cahill DJ, Lehrach H, Kreutzberger J, Kersten B. Mol Cell Proteomics. (2005) Oct;4(10):1558-68. Epub 2005 Jul 11. PMID: 16009969. · Profiling of alopecia areata autoantigens based on protein microarray technology. Lueking A, Huber O, Wirths C, Schulte K, Stieler KM, Blume-Peytavi U, Kowald A, Hensel-Wiegel K, Tauber R, Lehrach H, Meyer HE, Cahill DJ. Mol Cell Proteomics. (2005) Sep;4(9):1382-90. Epub 2005 Jun 6. PMID: 15939964. · Protein biochips: A new & versatile platform technology for molecular medicine. Lueking A, Cahill DJ, Müllner S. Drug Discov Today. (2005) Jun 1;10(11):789-94. Review. PMID: 15922937. · Bacterial protein microarrays for identification of new potential diagnostic markers for Neisseria meningitidis infections. Steller S, Angenendt P, Cahill DJ, Heuberger S, Lehrach H, Kreutzberger Journal Proteomics (2005)5(8):2048-55. PMID:15852346. · ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation. Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N. J Biological Chemistry (2004) Jun 25;279(26):27286-93. PMID: 15075326. · Cell-free protein expression and functional assay in nanowell chip format. Angenendt P, Nyarsik L, Szaflarski W, Glökler J, Nierhaus KH, Lehrach H, Cahill DJ, Lueking A. Analytical Chemistry (2004) Apr 1;76(7):1844-9. PMID: 15053642. · 3D protein microarrays: performing multiplex immunoassays on a single chip. Angenendt P, Glökler J, Konthur Z, Lehrach H, Cahill DJ. Analytical Chemistry (2003) Sep 1;75(17):4368-72. PMID: 14632038. · Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, Cahill DJ, Emili A, Fitzgerald DJ, Maguire PB. Blood. (2004) Mar 15;103(6):2096-104. Epub 2003 Nov 20. PMID: 14630798. · A nonredundant human protein chip for antibody screening and serum profiling. Lueking A, Possling A, Huber O, Beveridge A, Horn M, Eickhoff H, Schuchardt J, Lehrach H, Cahill DJ. Mol Cell Proteomics. (2003) Dec;2(12):1342-9. PMID: 14517340. · Next generation of protein microarray support materials: evaluation for protein and antibody microarray applications. Angenendt P, Glökler J, Sobek J, Lehrach H, Cahill DJ. J Chromatography A. (2003) 15;1009(1-2):97-104. PMID: 13677649. · A dual-expression vector allowing expression in E. coli and P. pastoris, including new modifications. Lueking A, Horn S, Lehrach H, Cahill DJ. Methods Molecular Biology (2003) 205:31-42. PMID: 12491878. · Toward optimized antibody microarrays: a comparison of current microarray support materials. Angenendt P, Glökler J, Murphy D, Lehrach H, Cahill DJ. Analytical Biochemistry (2002) Oct 15;309(2):253-60. PMID: 12413459. · Generation of minimal protein identifiers of proteins from two-dimensional gels & recombinant proteins. Schmidt F, Lueking A, Nordhoff E, Gobom J, Klose J, Seitz H, Egelhofer V, Eickhoff H, Lehrach H, Cahill DJ. Electrophoresis (2002) Feb;23(4):621-5. PMID:11870774. · Steps toward mapping the human vasculature by phage display. Arap W, Kolonin MG, Trepel M, et al., Cahill D, Troncoso P et al., Do KA, Logothetis CJ, Pasqualini R. Nature Medicine (2002) Feb;8(2):121-7. PMID: 11821895.

UNIVERSITY COLLEGE DUBLIN APPOINTMENTS

  • Full Professor
    University College Dublin, School of Medicine, Dublin 4, Ireland1 Oct 2010

DEGREES

  • BA
    Trinity College Dublin
  • PhD
    Dublin City University (DCU) IRL