The Integrative Biology Laboratory or "R" Lab is a pluri-disciplinary laboratory focusing on the functions of epithelia. We use physics, chemistry, engineering, molecular and cellular techniques to study secretory pathways. We combine an evolutionary approach from Planctomycetes to Human to new biophysical and optical methods ranging from cell "morphing" to Light Sheet Microscopy for 3D imaging as well as 3D bioprinting. Our ultimate goal is to achieve a continuum of knowledge from single bacteria excretion capacity to complex tissue secretion ability in an organism context. For example, we currently studide epithelia functions at the molecular level within artificial epithelial tissues (lung, kidney, gut) to create optimal conditions for cell biology and molecular approaches as well as drug screening on specifically targeted functions: protein expressing defect (cystic fibrosis, lung), water retention (kidney diseases), tumor formation (Epithelial Mesenchymal Transition EMT, metastasis..) or even infections. We also provide advices and optical set-ups to research groups and collaborate extensively with the private sectors (Carl Zeiss MicroImaging GmbH...).