RESEARCH INTERESTS

Hypoxia (low oxygen levels) and hypercapnia (high carbon dioxide levels) are a feature of several pathological conditions including lung disease. Our work has demonstrated that manipulation of environmental oxygen and carbon dioxide levels can significantly impact upon inflammatory signaling. Current projects are directed towards understanding the mechanisms underpinning the cellular sensitivity to carbon dioxide and cross talk between oxygen and carbon dioxide signaling pathways.

GRANTS

  • GRANT
    Characterisation of the pathogenic basis of an early-onset familial mucocutaneous ulcerative condition
    National Children's Research Centre Our Lady's Children's Hospital Crumlin (Ncrc)1 Oct 2018 - 30 Sep 2021
    People funded by this grant:
    • Wilson G,
    • Cummins E,
    • Taylor C
  • GRANT
    Carbon dioxide as a regulator of inflammatory signaling
    Science Foundation Ireland (SFI)1 Dec 2016 - 30 Nov 2021
    People funded by this grant:
    • Cummins E
  • GRANT
    Mechanisms of CO2-dependent regulation of NFkB signalling
    University College Dublin (UCD)1 Apr 2016 - 30 Sep 2017
    People funded by this grant:
    • Cummins E
  • GRANT
    The influence of carbon dioxide on (i) nuclear receptor and (ii) cancer signalling
    University College Dublin (UCD)1 Apr 2015 - 30 Sep 2016
    People funded by this grant:
    • Cummins E
  • GRANT
    The influence of carbon dioxide on inflammatory signaling
    University College Dublin (UCD)1 May 2013 - 31 Oct 2014
    People funded by this grant:
    • Cummins E
  • GRANT
    Examination of the effect of DMOG in a murine model of colitis with mice that lack HIF specifically in the gut
    University College Dublin (UCD)26 May 2008 - 1 Dec 2009
    People funded by this grant:
    • Cummins E