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Dr Fiona McGillicuddy

Dr

Fiona McGillicuddy

Lecturer/Assistant Professor
School of Medicine
01 716 6769
University College Dublin, School of Medicine, Conway Institute Belfield Dublin 4

RESEARCH INTERESTS

My research interests are to understand the link between diet - obesity - inflammation and cardiovascular disease. More specifically I'm interested at manipulating the obese phenotype with either diet (replacing saturated fats with less inflammatory monounsaturated fats) or supplementing high-fat diets with anti-inflammatory agents and determining the consequences for metabolic health and cholesterol metabolism. My studies focus on evaluating the effects of obesity and diet on the efflux capacity of high-density lipoprotein (HDL) particles ex vivo. We also use an in vivo model to track reverse cholesterol transport. In these studies J774 macrophages labeled with 3H-cholesterol are injected in vivo and movement of 3H-cholesterol from macrophages onto HDL particles and uptake of cholesterol into liver, bile and faeces is tracked. I have previously shown that inflammation markedly impairs this process and I hypothesize that high-fat diet induced inflammation will similarly impair reverse cholesterol transport. I am also interested in the consequences of inflammation on the cellular efflux capacity of macrophages and in particular am interested in the consequences for ABCA1-dependent efflux. Ongoing research is establishing the effects of M1 and M2 macrophage polarization on cholesterol efflux potential of macrophages. From a translational perspective I am interested in evaluating HDL function in human cohorts (lean, healthy obese and unhealthy (inflamed) obese individuals). These studies are ongoing and I am working closely with the Institute for Food and Health and Prof. Donal O'Shea's group at St. Vincent's Hospital to carry out these studies.

GRANTS

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GRANT
The impact of obesity on the microRNA cargo of high-density lipoprotein (HDL) particles
University College Dublin (UCD)
1 Apr 2018 - 31 Mar 2020
GRANT
Type 1 Diabetes Research
University College Dublin Foundation CLG
1 Apr 2018 - 30 Apr 2021
GRANT
Support for the research work of Dr McGillicuddy into diabetes in the UCD Conway Institute
University College Dublin Foundation CLG
6 Oct 2016 - 5 Oct 2019
GRANT
Investigating high-density lipoprotein (HDL) particle function and composition in metabolically healthy and unhealthy obesity.
University College Dublin (UCD)
1 Apr 2015 - 30 Sep 2016
GRANT
Functional consequences of obesity-induced adipose tissue inflammation on high-density lipoprotein (HDL) acceptor capacity and reverse cholesterol transport (RCT)
The Wellcome Trust (WT)
1 Mar 2012 - 16 Jun 2018