Assoc ProfessorJack Lambert

1. ACTG 064. A Phase 1 study of the safety and immunogenicity of DDI administered twice daily to HIV infected adults. (Clinical director of Study; PI Dr Ray Dolin). 2. ACTG 185 A Phase 3 Efficacy Trial of HIVIG administered to HIV infected pregnant women and their newborns. (Principal Investigator of the study). 3. ACTG 218 A Phase 1/2 Safety and Immunogenicity study of HIV vaccines administered to HIV infected children. (PI, Study Co-Chair) 4. ACTG 326 A Phase 1/2 Safety and immunogenicity study of HIV vaccines administered to HIV exposed children (PI, Study Chair) 5. AVEG 102 A Phase 1 study of an HIV vaccine (microgenesys) administered to HIV infected Pregnant women. (PI, Study Co-chair) 6. AVEG 104 A Phase 1 study of an HIV vaccine (genentech) administered to HIV infected pregnant women (PI, study Co-Chair) 7. AVEG 018 A Phase 2 study on an UBI microparticulate oral vaccine administered to HIV low risk seronegative adults. (PI, study chair) 8. Biovir Study A Phase 1/2 study of Combivir administered to HIV infected pregnant women and their newborns in an outpatient clinic in Rio de Janeiro, Brazil. (PI, study Co-Chair). 9. Hepatitis B Study A Phase 1/2 study of the administration of a Hepatitis B vaccine to newborns born to HIV infected mothers, Sao Paolo, Brazil. (study PI) 10. Penta 10/MRC A Phase 2 study of the administration of IL-2 to HIVinfected children followed as part of the European Paediatric HIV network. (study co-chair) 11. Brazil DDI Study A Phase 1 study of the bioequivelance of once daily versus twice daily DDI administered to HIV infected children. (study PI) 12. Fiocruz Study Establishment of a high risk gay mens cohort, assessing risk of acquisition of STD's in this population followed at the Oswaldo Cruz Foundation, Rio de Janeiro, Brazil (Co investigator) 13. Trichomonas Study: Evaluation of the prevalence of asymptomatic carriage of trichomonas in men attending the STD clinic at the Monroe County Health Department, Rochester NY 14. Herpes Study: Evaluation of a rapid HSV test kit in a population of STD patients followed at the Monroe County STD clinic, Rochester NY (co-investigator). 15. STD in Pregnant Women Study Establishment of a Cohort of High risk pregnant women at Fernandez Figeroia Institute, Rio de Janeiro, Brazil, and measurement of prevalence of STDs in this population. Comparison of standard culture techniques with LCR/PCR for GC and chlamydia . (PI, student mentor) 16. Uganda Peds vaccine study Assessment of attitudes to vaccination in a paediatric clinic in rural Uganda (student mentor) 17. HIV and syphilis study; Evaluation and characterization of pregnant women co-infected with syphilis and HIV in a pre-natal clinic in Rochester NY (study PI) 18. Paracoccidiomycosis and HIV Characterization of the association of paracoccidio and HIV (study co-investigator). 19. Post transfusion hepatitis C study Prevalence and incidence of Hepatitis C in a cohort of transplant patients followed at the Federal University of rio de Janeiro, Brazil. (thesis advisor) 20. Rapid HIV testing study-Rio de Janeiro and Port of Spain, Trinidad and Tobago. Study of the feasibilty of HIV rapid testing used in labor and delivery for the rapid diagnosis and treatment of HIV infected pregnant women. (study PI) 21. CDC cervical lavage study Measurement of mucosal antibody from cervical lavage specimens taken from HIV infected pregnant women who were part of the CDC/Thai AZT MTCT study. (consultant to CDC for mucosal immunity study, thesis advisor for student PhD thesis Dr Rutt) 22. Bacillary angiomatosis study Study of the characterization of relationship and manifestations of HIV and bacillary angiomatosis co-infected patients from a series of hospitals in Rio de Janeiro, Brazil (co-investigator). MCTC cohort Chennai Establishment and characterization of a cohort of HIV infected pregnant women followed at a tertiary Care centre, YRG, in Chennai, India (student mentor, co-investigator). 23. Paediatric HIV cohort Chennai Establishment and characterization of a cohort of HIV infected children followed at the YRG medical clinic in Chennai, India (student mentor, co-investigator). 24. MTCT cohort Rio Establishment of a cohort of HIV infected pregnant women from the maternities of the Federal University of Rio de Janeiro, Brazil (co-PI). 25. Paed AIDS cohort Rio Establishment of a cohort of HIV infected and exposed children followed at the Federal University of Rio de Janeiro, Brazil, (co-PI). 26. Seroprevalence of STD in PG women cohort Rio Establishment and characterization of STD's found in a cohort of pregnant women followed at the State University of Rio de Janeiro, Brazil, (study co-PI and thesis advisor). Hepatitis G study Rio Assessment of the prevalence of hepatitis G in a cohort from the Federal University of Rio de Janeiro, Brazil. (study co-PI and thesis advisor) 27. Pneumococcal vaccine study in HIV infected adults Assessment of the safety and immunogenicity of a conjugate Pn Vaccine in adults with symptomatic HIV infection. (study PI) 28. Transmission of HIV Subtypes in MTCT: Evaluation of the fidelity of transmission of chimeric HIV from mother to child in the Rio de Janeiro cohort. (study co-PI) 29. Quest study--quad therapy. Thymic reconstitution following HAART therapy in a cohort of adults followed in a multicentred GSK sponsored study (co-investigator). 30. Genotypic analysis of HIV infected children: Establishment of cohort and evaluation of genotypic resistance, following therapy, in children followed in the specialty clinics of the Federal University of Rio de Janeiro Brazil. (PI). 31. Protocol A4001050: A multi-centre open label expanded access trial of Maraviroc 32. Protocol M05-730: A phase III, randomised, open label, study of Lopinavir/ritonavir tablets versus soft gel capsules and once daily versus twice daily administration, when co-administered with NRTIs in antiretroviral naïve HIV-1 infected subjects 33. Protocol AI424136: A phase IV, open-label, randomised, multicentre trial assessing the efficacy of a treatment maintenance phase with unboosted vs. boosted Reyataz after an induction phase with Reyataz and Ritonavir in treatment naïve HIV patients (the INDUMA Study) 34. Euroresistance Study: Strategy to control spread of HIV drug resistance. Official European Commission supported programme 35. Therapeutic drug monitoring: use in HIV infected pregnant women 36. Immune response to Tuberculosis in people with and without HIV infection 37. Protocol M06-802: A phase III, randomised, open label study of Lopinavir/ritonavir tablets 800/200mg once-daily versus 400/100mg twice-daily when co-administered with Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in antiretroviral-experienced, HIV-1 infected subjects 38. Protocol CNA1095586: Study of Once Daily Abacavir/ Lamivudine versus Tenofir/ Emtricitabime, administered with Efavirenz in antiretroviral niave HIV-1 infected adult subjects. 39. Barriers to and enablers of hepatitis C screening and treatment among current or former injecting drug users in Ireland: A qualitative study from two perspectives. Co investigator with Dr Walter Cullen, PI. 40. Community Based Hepatitis C Treatment Study: Thompson Street Centre, Dublin 1. (PI) 41. Dublin HIV Cohort Study: Recruitment of patients with HIV from the major teaching hospitals in Dublin. (Co-Investigator) 42. Telzir/Hepatitis C Study: Phase 4 study of telzir treatment in patients with HepC coinfection (PI) 43. Protocol AI 447-016 A phase 2a/2b study of BMS-650032 in Combination with Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) in Treatment-Naïve Subjects with Genotypes 1 and 4 Chronic Hepatitis C Infection. 44. Protocol AI444010 A phase 2B Study of BMS-790052 in Combination with Peginterferon Alfa-2a (Pegasys) and Ribavirin in Treatment Naïve Subjects with Chronic Hepatitis C Genotype 1 and 4 infection. 45. S-COLLATE Study A Multicentre, Prospective, Observational, Non-Interventional Cohort Study Evaluating On-Treatment Predictors of Response in Subjects with HbeAg positive or HbeAg negative Chronic Hepatitis B Receiving Therapy with PEGASYS® (Peginterferon alfa-2a 40 KD) 46. Protocol GS-US-196-0103 A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Trial comparing 24 or 48 weeks of GS-9190, in Combination with Peginterferon Alpha 2a and Ribavirin, to 48 weeks of Peginterferon Alpha 2a and Ribavirin for the Treatment of Genotype-1 Chronic Hepatitis C Virus (HCV) Infection 47. Investigation into the reasons for HIV infected women not following up for their own care postpartum. MMUH/Rotunda. PI. 48. PANNA study Study on Pharmacokinetics of newly developed Antiretroviral agents in HIV-infected pregnant women (PANNA). 49. Therapeutic Drug Monitoring of Protease Inhibitors in Pregnancy as a Standard of Care¿ 50. A community based Hepatitis C treatment programme. 51. Friends of Rotunda ¿Screening for Hepatitis C: a prospective study at the Rotunda Maternity Hospital Dublin Ireland¿. 52. Telzir treatment of patients co-infected with HIV and Hepatitis C. 53. Woody Woodpecker Foundation to establish a MMUH/UCD link with Baphumelele Children¿s AIDS home, Capetown RSA 54. AI444-026 An Open-Label Re-treatment Study with Peg-Interferon Alfa-2a, Ribavirin and BMS-790052 With or Without BMS-650032 for Subjects With Chronic Hepatitis C, BMS. 55. AI447-028: Phase 3 Study with Asunaprevir and Daclatasvir (DUAL) for Null or Partial Responders to Peginterferon Alfa and Ribavirin (P/R), Intolerant or Ineligible to P/R Subjects and Treatment-Naive Subjects with Chronic Hepatitis C Genotype 1b Infection, BMS. 56. BI1241.20 A Phase III, Randomised, Partially Double-Blind and Placebo-Controlled Study of BI 207127 in Combination with FaldaprevirandRibavirin in Treatment-Naïve Patients with Chronic Genotype 1 HCVInfection, Boehringer Ingelheim. 57. Audit of HIV infected children in East London, RSA. 58. Global Adolescent HIV Research Project: The Passages Project 59. Homeless HepCheck. 60. PMTCT/ young adult ARV, RSA, PHASE 2. 61. Audit of HIV infected PASDP phase 2, RSA, Zambia, Kenya and Swaziland 62. Audit of HIV infected children PASDP phase 2, RSA, Eastern Cape. 63. HepCare project. Hepatitis C outreach project in collaboration with primary care. HEPCARE EUROPE Project. Third Health Programme EU commission funded project. UCD Medicine Research Individual Investigator UCD Medicine Research Centre: Infectious Diseases