DrJulie Worrell

I am focussed on understanding the contributions of stromal-immune cell interactions to tissue homeostasis, injury, and repair. My expertise lies in the area of lung remodelling following insult, with a particular focus on the contributions of immunomodulatory and extracellular matrix producing fibroblasts. Key to my work is my drive to obtain a more ‘geographical understanding’ of the lung microenvironment, specifically how cellular crosstalk spanning a particular region may promote tissue repair and remodelling. I utilise a combination of methods (e.g. transcriptomics, multi-parameter flow cytometry, multi-colour imaging and functional assays) to robustly phenotype and interrogate the functions/interactions of stromal and immune cell populations both in vivo and in vitro. This work incorporates physiologically relevant in vivo models of lung injury. A further translational aspect is added by my active engagement and collaboration with clinical researchers.