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DrMark Ledwidge

Adjunct Professor

School of Medicine

Orcid identifier0000-0001-7391-2949 (opens in a new tab)⁠
  • Adjunct Professor
    School of Medicine
  • University College Dublin, School of Medicine, Health Sciences Centre Belfield Dublin 4

RESEARCH INTERESTS

Marks research interests include: prevention of heart failure; natriuretic peptide and fibrosis in left ventricular dysfunction; iron deficiency; genetic and epigenetic approaches for the management of cardiovascular disease; pharmacogenomics.
He is inventor on a number of pending and granted patents. Mark is Co-Principal Investigator of the PARABLE study and the St Vincent’s Screening TO Prevent Heart Failure (STOP-HF) programme, which won a Royal College of General Practitioners Award in 2015 and has been incorporated into the 2017 American Heart Association/American College of Cardiology Guidelines.

GRANTS

  • CONTRACT RESEARCH
    Women at risk for heart failure
    Department of Health Ireland (DOH)7 Jan 2025 - 1 Aug 2027
    People funded by this grant:
  • GRANT
    KardiaTool
    EU Horizon 2020 Grant15 Jan 2018
    This project aims to create a portable device, KardiaPOC (point of care), for rapid qualitative and quantitative detection biomarkers of heart failure. It will be coupled to the KardiaLOC device, a disposable and low cost laboratory-on-a-chip device to detect the biomarkers from saliva samples. KardiaLOC will integrate sensors, actuators, micro-electromechanical systems, microelectronics, biochemicals, and functionalized magnetic nanoparticles in a single diagnostic device
  • GRANT
    Prospective, personalised, comparison of ARni with ArB in patients with natriuretic peptide eLEvation (PARABLE)
    Heartbeat Trust / Novartis3 Apr 2017
    Phase II, Double Blind, Double Dummy, Investigator-Led Clinical Trial. 2016-2020
  • GRANT
    Targeting cardiac fibrosis for heart failure treatment (FIBRO-TARGETS)
    Ec Framework (Fp7)1 Sep 2013 - 31 Aug 2018
    People funded by this grant:
    • McDonald K,
    • Watson C,
    • Ledwidge M
  • GRANT
    "Immunomodulatory-matrix metalloproteinase (MMP) inhibition with tetracyclines in obesity, diabetes and asymptomatic left ventricular diastolic dysfunction: impact on MMP-9 levels and cardiovascular structure and function."
    Health Research Board1 Jul 2013 - 30 Jun 2017
    People funded by this grant:
    • Ledwidge M