DrRebecca Corrigan

My research involves the characterisation of nucleotide-controlled stress signalling pathways in bacteria and their importance for infection and antibiotic resistance. My lab’s current focus is on the study of the stringent response alarmones (p)ppGpp in Staphylococcus aureus. S. aureus is a human pathogen responsible for a vast array of disease and morbidity worldwide, a problem that is exacerbated by the spread of antibiotic-resistant strains such as methicillin resistant S. aureus (MRSA). The stringent response alarmones are ubiquitous signalling nucleotides essential for bacterial stress survival and implicated in chronic infection, antimicrobial resistance/tolerance and host-pathogen interactions. My lab integrate microbial physiology and genetics, biochemistry, structural biology and immunology to provide an over-arching view of the importance of this signalling system for disease.