We live in an exciting age- the ‘omics’ revolution, where genomics-powered genetics and high-throughput phenotyping using temporal resolution are revolutionizing plant physiology. These advances require an interdisciplinary vision and the development of new methodologies using computer science and statistics. My experience with abiotic stress physiology in crop species, and its translation into field production, led me to inquiry about the “genetic mechanisms underlying stress adaptation using resilient crop species.” To achieve this goal, I concentrate on the genomic signatures of stress adaptation by performing association models using naturally occurring genetic diversity and high-throughput phenotyping. My research vision also integrates temporal resolution of plants adaptation to stress.