ProfessorDavid MacHugh
Full Professor
School of Agriculture and Food Science
Orcid identifier0000-0002-8112-4704 (opens in a new tab)
- Full ProfessorSchool of Agriculture and Food Science
- 01-7166256
- University College Dublin, School of Agriculture and Food Science, Veterinary Science Centre Belfield Dublin 4
RESEARCH INTERESTS
Functional genomics and systems biology of host-pathogen interactions in domestic animals with a specific focus on diseases caused by mycobacterial infections; particularly, bovine tuberculosis caused by infection with Mycobacterium bovis and Johne's disease in cattle caused by infection with M. avium subspecies paratuberculosis.
Epigenomics of economically important traits in livestock. Evolutionary origins and population genomics of domestic cattle.
Palaeogenomics of domestic livestock and their wild ancestors. Genome mapping in domestic animal species.
Equine physiological genomics for performance and health traits.
Application of genomics to commercial animal breeding and food production.
As an independent Principal Investigator, I have managed, coordinated and delivered many large research programmes in these areas since 2000 (18 years).
This research work has contributed to the generation and exploitation of significant intellectual property and Prof. MacHugh is a co-founder and shareholder in IdentiGEN Ltd. (www.identigen.com), Equinome Ltd. (www.equinome.com) and Plusvital Ltd. (www.plusvital.com).
Epigenomics of economically important traits in livestock. Evolutionary origins and population genomics of domestic cattle.
Palaeogenomics of domestic livestock and their wild ancestors. Genome mapping in domestic animal species.
Equine physiological genomics for performance and health traits.
Application of genomics to commercial animal breeding and food production.
As an independent Principal Investigator, I have managed, coordinated and delivered many large research programmes in these areas since 2000 (18 years).
This research work has contributed to the generation and exploitation of significant intellectual property and Prof. MacHugh is a co-founder and shareholder in IdentiGEN Ltd. (www.identigen.com), Equinome Ltd. (www.equinome.com) and Plusvital Ltd. (www.plusvital.com).
GRANTS
- GRANTFEATUREDTri-Partite Collaborative: Targeted Genome Editing To Understand And Enhance Genetic Resistance To Bovine Tuberculosis In Cattle (TARGET-TB)Dept. Agriculture Food and the Marine (Dafm)1 May 2018 - 30 Apr 2021People funded by this grant:
- MacHugh D,
- Gordon S
- GRANTFEATURED36th International Society for Animal Genetics ConferenceScience Foundation Ireland (SFI)22 Jun 2017 - 21 Jul 2017People funded by this grant:
- MacHugh D
- GRANTFEATUREDHigh throughput transcriptomics for animal disease including zoonosisScience Foundation Ireland (SFI)1 Jan 2016 - 31 Dec 2016People funded by this grant:
- Gordon S,
- MacHugh D
- GRANTFEATUREDH2020 Catalyst Award: Development of Next- Generation Control Tools for Bovine Tuberculosis: A One Health ApproachScience Foundation Ireland (SFI)1 Dec 2015 - 1 Dec 2017People funded by this grant:
- MacHugh D,
- Gordon S
- GRANTFEATUREDComparative immunogenomics of the human and animal response to mycobacterial infection.Irish Research Council (IRC)1 Oct 2015 - 30 Sep 2017People funded by this grant:
- MacHugh D
- GRANTFEATUREDNovel bovine tuberculosis diagnostics based on bovine circulating serum microRNAsCoordenacao De Aperfeicoamento De Pessoal De Nivel Superior (Capes)1 Feb 2014 - 31 Jan 2015People funded by this grant:
- MacHugh D
- GRANTFEATUREDDevelopment and Validation of Novel Circulating microRNA Biomarkers for Bovine Tuberculosis.Science Foundation Ireland (SFI)1 Jan 2014 - 30 Apr 2015People funded by this grant:
- MacHugh D
- GRANTFEATUREDFunctional genomics and proteomics studies of bovine tuberculosisScience Foundation Ireland (SFI)1 Sep 2009 - 1 Sep 2014People funded by this grant:
- MacHugh D,
- Gordon S
- GRANTSFI Centre for Research Training in Genomics Data Science (Student Cohort 3 - CRT) [John F O'Grady]University College Dublin (UCD)12 Mar 2019 - 11 Sep 2026People funded by this grant:
- MacHugh D,
- Gormley C,
- MacHugh D
- GRANT2016 Internal funding schemeUniversity College Dublin (UCD)20 Dec 2016 - 19 Dec 2019People funded by this grant:
- MacHugh D
- GRANTHarvesting Knowledge from Big Data in Agriculture and FoodScience Foundation Ireland (SFI)15 Oct 2016 - 14 Dec 2016People funded by this grant:
- MacHugh D
- GRANTA high-resolution survey of genome diversity in the Kerry cattle breed using high-throughput pan-genomic 54K single nucleotide polymorphism (SNP) chipsDept. of Agriculture Fisheries & Food (Daff)1 Apr 2010 - 31 Mar 2011People funded by this grant:
- MacHugh D
- GRANTInvestigation of genetic basis of bovine fertility using gene expression and genome-wide association dataTeagasc1 Oct 2009 - 30 Sep 2010People funded by this grant:
- MacHugh D
- GRANTA high-resolution survey of genome diversity in the Galway sheep breed using pan-genomic 60K single nucleotide polymorphism (SNP) chipsDept. of Agriculture Fisheries & Food (Daff)1 Apr 2009 - 31 Mar 2010People funded by this grant:
- MacHugh D
- GRANTMacroSys-Macrophage Systems Biology Applied to Disease ControlEc Framework (Fp7)1 Nov 2008 - 31 Oct 2012People funded by this grant:
- MacHugh D
- GRANTFine mapping and identification of themutation responsible for inherited ovine arthrogypsisResearch Ireland11 Jun 2007 - 3 Sep 2007People funded by this grant:
- MacHugh D
- GRANTDevelopment of high-throughout genetic markers for beef traits using variation in genes subject to genomic imprintingDept. of Agriculture Fisheries & Food (Daff)1 Oct 2006 - 30 Sep 2009People funded by this grant:
- MacHugh D
- GRANTIdentification of resistance genes via functional genomics expression studies of bovine macrophages exposed to three economically important animal pathogensDept. of Agriculture Fisheries & Food (Daff)1 Oct 2006 - 30 Sep 2009People funded by this grant:
- MacHugh D
- GRANTIrish Population Genomics: A foundation for pharmacogenomic and complex disease researchScience Foundation Ireland (SFI)1 Feb 2006 - 1 Feb 2007People funded by this grant:
- MacHugh D
- GRANTFine--mapping and identification of the mutation responsible for inherited ovine arthrogryposis multiplex congenita (AMC): development of an animal model for human AMCScience Foundation Ireland (SFI)1 Oct 2005 - 31 Jan 2009People funded by this grant:
- MacHugh D
- GRANTStudy of gene expression in peripheral blood mononuclear cells from cattle infected with bovine tuberculosisResearch Ireland15 Jun 2005 - 13 Sep 2005People funded by this grant:
- MacHugh D
- GRANTStudy of gene expression in peripheral blood mononuclear cells (PBMC) from cattle infected with Bovine TBScience Foundation Ireland (SFI)13 Jun 2005 - 13 Jun 2006People funded by this grant:
- MacHugh D
- GRANTUndergraduate Student Summer PlacementResearch Ireland1 Jun 2004 - 30 Aug 2004People funded by this grant:
- MacHugh D
- GRANTAnalysis of Mammalian Physiological and genetic regulatory networks using cDNA microarramsScience Foundation Ireland (SFI)1 Oct 2002 - 31 Mar 2008People funded by this grant:
- MacHugh D
- GRANTAnalysis of mammalian physiological and genetic regulatory networks using cDNA microarraysResearch Ireland1 Oct 2002 - 3 Mar 2008People funded by this grant:
- MacHugh D