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Professor David MacHugh

Professor

David MacHugh

Full Professor
School of Agriculture and Food Science
01-7166256
University College Dublin, School of Agriculture and Food Science, Veterinary Science Centre Belfield Dublin 4

RESEARCH INTERESTS

Functional genomics and systems biology of host-pathogen interactions in domestic animals with a specific focus on diseases caused by mycobacterial infections; particularly, bovine tuberculosis caused by infection with Mycobacterium bovis and Johne's disease in cattle caused by infection with M. avium subspecies paratuberculosis. Epigenomics of economically important traits in livestock. Evolutionary origins and population genomics of domestic cattle. Palaeogenomics of domestic livestock and their wild ancestors. Genome mapping in domestic animal species. Equine physiological genomics for performance and health traits. Application of genomics to commercial animal breeding and food production. As an independent Principal Investigator, I have managed, coordinated and delivered many large research programmes in these areas since 2000 (18 years). This research work has contributed to the generation and exploitation of significant intellectual property and Prof. MacHugh is a co-founder and shareholder in IdentiGEN Ltd. (www.identigen.com), Equinome Ltd. (www.equinome.com) and Plusvital Ltd. (www.plusvital.com).

GRANTS

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GRANTFEATURED
Tri-Partite Collaborative: Targeted Genome Editing To Understand And Enhance Genetic Resistance To Bovine Tuberculosis In Cattle (TARGET-TB)
Dept. Agriculture Food and the Marine (DAFM)
1 May 2018 - 30 Apr 2021
GRANTFEATURED
36th International Society for Animal Genetics Conference
Science Foundation Ireland (SFI)
22 Jun 2017 - 21 Jul 2017
GRANTFEATURED
Development of Next-Generation Control Tools for Bovine Tuberculosis: A One Health Approach
Science Foundation Ireland (SFI)
1 Sep 2016 - 31 Aug 2022
GRANTFEATURED
High throughput transcriptomics for animal disease including zoonosis
Science Foundation Ireland (SFI)
1 Jan 2016 - 31 Dec 2016
GRANTFEATURED
H2020 Catalyst Award: Development of Next- Generation Control Tools for Bovine Tuberculosis: A One Health Approach
Science Foundation Ireland (SFI)
1 Dec 2015 - 1 Dec 2017
GRANTFEATURED
Comparative immunogenomics of the human and animal response to mycobacterial infection.
Irish Research Council (IRC)
1 Oct 2015 - 30 Sep 2017
GRANTFEATURED
Novel bovine tuberculosis diagnostics based on bovine circulating serum microRNAs
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
1 Feb 2014 - 31 Jan 2018
GRANTFEATURED
Development and Validation of Novel Circulating microRNA Biomarkers for Bovine Tuberculosis.
Science Foundation Ireland (SFI)
1 Jan 2014 - 30 Apr 2015
GRANTFEATURED
Functional genomics and proteomics studies of bovine tuberculosis
Science Foundation Ireland (SFI)
1 Sep 2009 - 31 Aug 2015
GRANT
Harvesting Knowledge from Big Data in Agriculture and Food
Science Foundation Ireland (SFI)
15 Oct 2016 - 14 Dec 2016
GRANT
Investigation of genetic basis of bovine fertility using gene expression and genome-wide association data
Teagasc
1 Oct 2010 - 30 Sep 2014
GRANT
A high-resolution survey of genome diversity in the Kerry cattle breed using high-throughput pan-genomic 54K single nucleotide polymorphism (SNP) chips
Dept. of Agriculture Fisheries & Food (DAFF)
1 Apr 2010 - 30 Sep 2017
GRANT
A high-resolution survey of genome diversity in the Galway sheep breed using pan-genomic 60K single nucleotide polymorphism (SNP) chips
Dept. of Agriculture Fisheries & Food (DAFF)
1 Apr 2009 - 31 Mar 2010
GRANT
MacroSys-Macrophage Systems Biology Applied to Disease Control
EC Framework (FP7)
1 Nov 2008 - 31 Oct 2012
GRANT
Fine mapping and identification of themutation responsible for inherited ovine arthrogypsis
Science Foundation Ireland
11 Jun 2007 - 3 Sep 2007
MacHugh D
GRANT
Development of high-throughout genetic markers for beef traits using variation in genes subject to genomic imprinting
Dept. of Agriculture Fisheries & Food (DAFF)
1 Oct 2006 - 30 Sep 2009
GRANT
Identification of resistance genes via functional genomics expression studies of bovine macrophages exposed to three economically important animal pathogens
Dept. of Agriculture Fisheries & Food (DAFF)
1 Oct 2006 - 31 Mar 2009
GRANT
Irish Population Genomics: A foundation for pharmacogenomic and complex disease research
Science Foundation Ireland (SFI)
1 Feb 2006 - 31 Jan 2007
GRANT
Fine--mapping and identification of the mutation responsible for inherited ovine arthrogryposis multiplex congenita (AMC): development of an animal model for human AMC
Science Foundation Ireland (SFI)
1 Oct 2005 - 31 Jan 2009
GRANT
Study of gene expression in peripheral blood mononuclear cells from cattle infected with bovine tuberculosis
Science Foundation Ireland
15 Jun 2005 - 13 Sep 2005
MacHugh D
GRANT
Study of gene expression in peripheral blood mononuclear cells (PBMC) from cattle infected with Bovine TB
Science Foundation Ireland (SFI)
13 Jun 2005 - 2 Sep 2005
GRANT
Undergraduate Student Summer Placement
Science Foundation Ireland
1 Jun 2004 - 30 Aug 2004
MacHugh D
GRANT
Analysis of Mammalian Physiological and genetic regulatory networks using cDNA microarrams
Science Foundation Ireland (SFI)
1 Oct 2002 - 31 Mar 2008
GRANT
Analysis of mammalian physiological and genetic regulatory networks using cDNA microarrays
Science Foundation Ireland
1 Oct 2002 - 3 Mar 2008
MacHugh D
GRANT
Award: Molecular Genetic Analysis of Bull Fertility via Mitochondrial DNA Sequencing and in vitro Fertilisation
University College Dublin (UCD)
1 Apr 2001 - 1 Mar 2002
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